ABSTRACT
Breast cancer is the one of the most frequent neoplasm in women. In the last decades, detection of disease in earlier clinical stages has improved prognosis, however five-year disease-free survival still remains at about 72%. For this reason, continuing efforts to establish reliable prognostic markers are made. The presence of lymph node metastasis is one of the most important prognostic factors in breast cancer. Studies show that D2-40 immuno-stain demonstrated a significant higher detection of LVI as compared with routine H&E staining in early breast cancer. LVI is associated with axillary lymph node metastases and a long-term prognostic factor. A precise identification of LVI would have a strong clinical impact for breast cancer patients. In this study, we aim to demonstrated.LVI as a significant predictor of poor prognosis in patients with lymph node-negative patients with primary invasive breast cancer and its association with other known parameters such as tumour size, tumour grade, nodal metastasis and age